24.11.2007

Short history of medicine in Romania

I'm not going to tell you about the prehistorical age or so. I am going to write about a few names that made a difference in the hole medical world and gave their contribution to the large amount of knowledge we are supposed to learn as medical students.
If you go and search on pubmed.com for ˝romanian˝ you're going to find 26756 articles. All researchers, maybe not all doctors, but still remarkable every single one of them. Even so, that doesn't tell you too much, does it?! That's why I'm going to tell you about those romanians that discovered things you can relate to.

Grigore T. Popa - talamo-hipofizar portal sistem with Henry Fielding

Victor Babeş
- Babeş-Ernst bodies: Metachromatic intracellular deposits of polyphosphate found in Corynebacterium diphtheriae when the bacteria are grown on when the bacteria are grown on sub optimal media.
Babeş-Negri bodies: inclusions in rabies-infected nervous cells
Babesia: parasites of the genus Hemosporidiae
Babesiosis (Piroplasmosis):severe rare desease, deadly sometimes, caused by an intracelular protozoa, Babesia microti.

Ana Aslan - founding figure of gerontology and geriatrics in Romania. 1952 - vitamin H3 (Gerovital), geriatric product patented in more than 30 countries. The genuine recipe was only known by Ana Aslan. The drugs existing on the market today are made after the original medicine but are not directly related to Ana Aslan's medicine. They are only using the fame of the original name. Especially the ones produced outside Romania.

Mihai Ciucă - disovered the lysogenic conversion of bacteria

Nicolae Paulescu - Romanian professor, he had been working on diabetes since 1916, and had isolated insulin (which he called pancreatine) about a year before the Canadians, Frederick Banting and John Macleod, that received the Nobel Prize in Medicine in 1923. Later, all became known, but it was too late. (wikipedia.com)

Ioan Cantacuzino - His discoveries were relevant in the treatment of cholera, epidemic typhus, tuberculosis, and scarlet fever. As a disciple of Mechnikov, he devoted part of his research to expanding on the latter's field of interest (phagocytes, the body's means of defence against pathogens, as well as the issue of immunity and invertebrates). He invented the notion of contact immunity.

Dimitrie Gerota - Gerota's method - Injection of the lymphatics with a dye that is soluble in chloroform or ether but not in water; alkannin, red sulfide of mercury, and Prussian blue are said to be suitable for this purpose.
Gerota's capsule/fascia - Renal fascia - The condensation of the fibroareolar tissue and fat surrounding the kidney to form a sheath for the organ.

Gheorghe Marinescu - neurologyst - Early in his career he published with the bacteriologist Victor Babeş and the French pathologist Paul Oscar Blocq a much needed atlas on the pathological histology of the nervous system. His description with Blocq of a case of parkinsonian tremor due to tumour in the substantia nigra, in 1893, was the basis for Édouard Brissaud's theory that parkinsonism occurs as a consequence of damage to the substantia nigra. With Paul Blocq he was the first to describe senile plaques and with Romanian neurologist Ion Minea confirmed in 1913 Hideyo Noguchi's discovery of Treponema pallidum in the brain in patients with general paresis. His monumental work La Cellule Nerveuse, with a preface by Santiago Ramon y Cajal, appeared in 1909.

George Emil Palade - used electron microscopy to study the internal organization of such cell structures as mitochondria, chloroplasts, the Golgi apparatus, and others. His most important discovery was related made while using an experimental strategy known as a pulse-chase experiment. In the experiment Palade and his colleagues were able to confirm an existing hypothesis that a secretory pathway exists and that the Rough ER and the Golgi apparatus function together. His name has become attached to the Weibel-Palade bodies (a storage organelle unique to the endothelium, containing von Willebrand factor and various proteins). In 1974, he shared the Nobel Prize in Physiology or Medicine with Albert Claude and Christian de Duve, for his discoveries concerning the structure and function of organelles in biological cells.

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